Recent Publications 2006-Present (Updated 11/17/2011)

2011

Barrilleaux B. and Knoepfler PS. Inducing iPS cells to escape the dish. Cell Stem Cell. 2011 Aug 5;9(2):103-11.

Varlakhanova NV, Cotterman RF, Bradnam K, Korf I, and Knoepfler PS. Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells. Epigenetics & Chromatin. 2011 Nov 4;4(1):20.

 

Knoepfler PS. My Year As A Stem Cell Blogger. Nature. 475(7357):425.

Barrilleaux B. and Knoepfler PS. Overexpression of oncogenes in human cells using ecotropic lentivirus for enhanced biosafety. J Vis Exp. 2011 Jul 24;(53). pii: 2822

Domínguez-Frutos E, López-Hernández I, Vendrell V, Neves J, Gallozzi M, Gutsche K, Quintana L, Sharpe J, Knoepfler PS, Eisenman RN, Trumpp A, Giráldez F, Schimmang T. N-myc Controls Proliferation, Morphogenesis, and Patterning of the Inner Ear. J. Neurosci 2011 31(19): 7178-7189.

2010

Varlakhanova N, Cotterman R, deVries W, Morgan J, Donahue LR, Murray S, Knowles BB, and Knoepfler PS. myc maintains embryonic stem cell pluripotency and self-renewal. Differentiation. 2010. 80(1):9-19.

Wey, A Ceredeno VM, Pleasure D, and Knoepfler PS. c-myc and N-myc regulate self-renewal, pluripotency, and metabolism of neural stem cells to direct brain growth. Cerebellum 2010 Dec;9(4):537-47.

Wey A, and Knoepfler PS. c-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain. 2010. OncoTarget. 1(2), 1-10.

Wey A, and Knoepfler PS. C-myc and N-myc in the developing brain. Aging. 2010. 2(5):261-2.

Kuwahara A, Hirabayashi Y, Knoepfler PS, Taketo MM, Sakai J, Kodama T, Gotoh Y. Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex. Development. 2010. 137(7):1035-44.

Knoepfler PS and Bush KM. Software for the efficient management of mouse colonies. Dis Model Mech. 2010 Jan-Feb;3(1-2):9-10.

 

2009

Knoepfler PS. Journal Club. A cell biologist looks at the risk and promise of a new insight into stem cells and cancer. Nature 2009. 457(228):361.

Knoepfler PS. Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine. Stem Cells 2009. 27(5): 1050-1056.

Cotterman R and Knoepfler PS. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b. PLoS One 2009 4(6): e5799.

Varlakhanova, NV, and Knoepfler PS. Acting locally and globally: Myc’s ever-expanding roles on chromatin. Cancer Research 2009 69:7487-90.

Chen D, Pacal M, Wenzel P, Knoepfler PS, Leone G, and Bremner R. E2F-dependent division and E2F-independent survival in the developing retina. Nature 2009 462(7275):925-9.

 

2008

Knoepfler PS. Why Myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell. 2008. 2(1):18-21

Martins RA, Zindy F, Donovan S, Zhang J, Pounds S, Wey A, Knoepfler PS, Eisenman RN, Roussel MF, and Dyer, MA. N-Myc coordinates retinal growth with eye size during mouse development. Genes and Development 2008. 22(2): 179-93.

Knoepfler PS. Stem cells on the brain. Arch Neurology 2008. 65(3): 311-315.

Cotterman R, Jin VX, Krig SR, Lemen JM, Wey A, Farnham PJ, and Knoepfler PS. N-Myc regulates a widespread euchromatic program in the human genome partially independent of its role as a classical transcription factor. Cancer Research 2008. 68(23): 9654-9662.

Laurenti E, Varnum-Finney B, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS,Cheng PF, MacDonald R, Eisenman RN, Bernstein ID, Trumpp A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 2008. 3(6): 611-624.

 

2007

Ota S, Zhou ZQ, Knoepfler PS, and Hurlin PJ. Activities of N-Myc in the developing limb link control of skeletal size with digit separation. Development 2007. 134(8):1583-92.

Knoepfler PS. Myc goes global: new tricks for an old oncogene. Cancer Res 2007. 67(11):5061-3.

Habib T, Tsang M, Moreno de Alboran I, Nicks A, Park H, Wilson L, Knoepfler PS, Andrews S, Rawlings D, Eisenman RN, and Iritani BM. Myc Stimulates Lymphocyte Differentiation and Amplifies Calcium Signaling. Journal of Cell Biology. 2007, 179(4):717-31.

 

2006

Knoepfler PS, Kenney AM. Neural precursor cycling at Sonic speed: N-Myc pedals, GSK-3 brakes.Cell cycle. 2006, 5(1): 47-52.

Knoepfler PS, Zhang XY, Cheng PF, Gafken PR, McMahon SB, and Eisenman RN. Myc influences global chromatin structure. Embo J 2006. 25(12): 2723-34.

Zindy F*, Knoepfler PS*, Xie S, Sherr CJ, Eisenman RN, Roussel MF. N-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar development.Proc Natl Acad Sci U S A. 2006, 103(31):11579-11583. (*co-first authors).

Hatton BA*, Knoepfler PS*, Kenney AM, Rowitch DH, de Alboran IM, Olson JM, and Eisenman RN. N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth. Cancer Res. 2006, 66 (17): 1-7. (*co-first authors).