Scoop on this week’s Paris human gene editing/genetic modification meetings

This week there will be two meetings in Paris as part of the ongoing international dialogue on human genetic modification/human gene editing, CRISPR, and figuring out a wise path forward.

Paris CRISPR Meeting

A one-day workshop will be held on April 28th “jointly organised by the Federation of European Academies of Medicine (FEAM), the UK Academy of Medical Sciences and the French Academy of Medicine; with kind support from the InterAcademy Partnership for Health and the French Academy Foundation. It will be held at the French Academy of Medicine in Paris.”

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If you’ve had a stem cell treatment, how was your experience?

stem cell treatments

Have you had a stem cell treatment and if so, what was your experience like?

I really value the diversity of readers on this blog from all over the world. I know we have a lot of readers who are patients and have had stem cell treatments. Every week I get emails from people asking about stem cell treatments and clinics.

I encourage you to weigh in here in the comments if you or a loved have had a stem cell treatment. What was it like? If it was positive, why did you feel that way? Same if it was negative.

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Weekend science reads: lab labor, pubs, CRISPR shrooms, money & more

mushroom

Wikipedia image

Here are some weekend science reads for you.

A new type of “magic” mushroom? MIT Tech Review on lack of oversight of new GMO foods coming to your plate.

DrugMonkey’s piece on lab labor and specifically whether undergrads “count” drew a lot of comments there. Of course they count in my view.

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The only frozen yogurt that really listens to you

From a visit to Portland a few weeks back and going to Nectar frozen yogurt.

Is this one listening to you or monitoring your diet?

I got a combo of chocolate and pistachio instead, which was delicious.

This got me thinking of course whether all those folks at the NSA “listening” to us have their very own fro yo service at their commissary so they don’t have to go out for a treat and stop their surveillance.

If so what might the most popular flavor be? Bug?Frozen Yogurt

Pain in a dish? Drug testing bench to bedside with IPS cells

A new study on treating pain with a unique stem cell connection caught my attention. The paper was from a team at Pfizer led by Edward B. Stevens.

Talk about bench to bedside, these researchers went all the way from patients to patient somatic cells to reprogrammed IPSC to neurons to model pain in a dish and then test a drug in a dish, and then finally to test the drug in the patients. The drug in questions is the Nav1.7 blocker, PF-05089771.

The team found that neurons made from IPS cells generated from patients suffering from inherited erythromelalgia (IEM) exhibited differences in activity compared to controls. While I’m not sure that we can call these excitability differences literally “pain”, measuring them may serve as a useful readout assay for studying drugs that could treat pain.

inherited erythromelalgia

You can see one readout of the differences in the IEM patient neurons versus controls in Figure 2B above.

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